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Search Results for " cgrp receptor "

29

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8682	Vazegepant hydrochloride Vazegepant HCl	CGRP Receptor	GPCR/G Protein; Neuroscience
	Vazegepant hydrochloride (Vazegepant HCl) 是一种用于偏头痛的鼻用 gepant，是一种高度亲和性CGRP 受体拮抗剂 (hCGRPKi=0.023 nM)。它可能有助于有效管理 COVID-19 相关肺部炎症。
T17194	Ubrogepant MK-1602	CGRP Receptor	GPCR/G Protein; Neuroscience
	Ubrogepant (MK-1602) 是新型的、口服有效的降钙素基因相关肽受体拮抗剂。Ubrogepant 有潜力用于急性偏头痛的相关研究。
TP1040	Calcitonin (salmon) 鲑降钙素,Calcitonin salmon,Salmon calcitonin	CGRP Receptor	GPCR/G Protein; Neuroscience
	Calcitonin (salmon) 是一种阿米林和卡西宁受体的双激动剂，是一种钙调节激素，能够刺激骨的生成并能抑制骨吸收。
T12293L	Olcegepant BIBN-4096,BIBN 4096BS	CGRP Receptor	GPCR/G Protein; Neuroscience
	Olcegepant (BIBN-4096) 是一种选择性的降钙素基因相关肽1 (CGRP1) 受体拮抗剂，IC50=0.03 nM，Ki=14.4 pM。
T4610	Rimegepant BMS 927711,BMS-927711,BMS927711,BHV-3000	CGRP Receptor	GPCR/G Protein; Neuroscience
	Rimegepant (BMS 927711) 是一种有效的降钙素基因相关肽 (CGRP) 受体拮抗剂，其 Ki=0.027 nM，IC50=0.14 nM。
T6590	MK-3207 Hydrochloride MK-3207 HCl	CGRP Receptor	GPCR/G Protein; Neuroscience
	MK-3207 Hydrochloride (MK-3207 HCl) 是口服具有活力的CGRP receptor 拮抗剂，IC50=0.12 nM，Ki=0.024 nM。
T13453	CGRP antagonist 1	CGRP Receptor	GPCR/G Protein; Neuroscience
	CGRP antagonist 1是高效 CGRP 受体拮抗剂，Ki 值分别为 35nM，IC50 值为 57 nM。CGRP antagonist 1可用于研究心血管疾病和神经血管疾病。
TP1323	CGRP 8-37 (rat)	CGRP Receptor	GPCR/G Protein; Neuroscience
	CGRP 8-37 (rat) 是 CGRP receptor 拮抗剂，是一种可作用于大鼠的 CGRP片段，具有潜在的抗伤害作用，可诱导动脉松弛。
TP1134L	HCGRP-(8-37) acetate HCGRP-(8-37) acetate (119911-68-1 free base)	CGRP Receptor	GPCR/G Protein; Neuroscience
	HCGRP-(8-37) acetate 是一种人降钙素基因相关肽 (hCGRP) 片段醋酸盐，也是 CGRP 受体的拮抗剂。
TP1200	CGRP (83-119), rat TFA Calcitonin Gene Related Peptide(83-119), rat TFA	Others	Others
	CGRP (83-119), rat TFA (Calcitonin Gene Related Peptide(83-119), rat TFA) 是一种由 37 个氨基酸组成的神经肽降钙素家族，通过降钙素受体样受体起作用。
TP1257L	Adrenomedullin (AM) (22-52), human acetate Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base）	CGRP Receptor	GPCR/G Protein; Neuroscience
	Adrenomedullin (AM) (22-52), human acetate 是猫后肢血管床中 CGRP 受体和肾上腺髓质素受体的拮抗剂。
T75978	β-CGRP, human TFA
	β-CGRP, human TFA (Human β-CGRP TFA) 是一种降钙素肽，通过降钙素受体样受体CRLR 与RAMP 的复合物起作用，在细胞体系中，对 CRLR/RAMP1 和 CRLR/RAMP2 的IC50值分别为 1 nM 和 300 nM。
T30537	BMS-694153 BMS694153,BMS 694153
	BMS-694153 is a potent and selective CGRP receptor antagonist.
TP1134	HCGRP-(8-37) Human α-CGRP (8-37)
	Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist
T70820	MK-8825
	MK-8825 is a CGRP receptor antagonist.
T16093	Telcagepant MK-0974	Others	Others
	Telcagepant is an orally active antagonist of calcitonin gene-related peptide (CGRP) receptor (Kis: 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively).
T39522	HTL22562
	HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute treatment of migraine.
T38734	Vazegepant Zavegepant,BHV-3500
	Vazegepant is an intranasal CGRP receptor antagonist utilized for conducting acute migraine research.
TP2044	α-CGRP(human) α-CGRP (human)
	Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.
T76363	[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat
	[Tyr22]CalcitoninGene Related Peptide, (22-37), rat 是一种大鼠降钙素基因相关肽 (CGRP) 的 22-37 片段，靶向CGRP 受体和腺苷酸环化酶。降钙素 (calcitonin) 主要由甲状腺 C 细胞产生，而 CGRP 则分泌并储存在神经系统中。
T26796	BI-44370
	BI-44370, a CGRP (calcitonin gene-related peptide) receptor antagonist, can be used to treat migraines and other chronic pain.
T12293	Olcegepant hydrochloride BIBN-4096 hydrochloride,BIBN4096BS hydrochloride	Others	Others
	Olcegepant hydrochloride is a potent and selective non-peptidethe calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (with IC50 of 0.03 nM for human CGRP).
TP1203	CGRP(83-119), rat Calcitonin Gene Related Peptide (CGRP) (83-119), rat
	Calcitonin Gene Related Peptide (CGRP) (83-119), rat is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor.
TP2049	CRSP-1
	Endogenous central calcitonin (CT) receptor agonist that stimulates cAMP formation at a potency 350-fold greater than CT (ED50 values are 0.2 and 71 nM respectively). Displays no activity at calcitonin-gene related peptide (CGRP) and adrenomedullin recept
T21558	MK-3207
	MK-3207是口服生物相容性的CGRP 受体拮抗剂，IC50和 Ki 分别为 0.12 nM 和 0.024 nM，对 AM1，AM2，CTR 和 AMY3 的抑制性较弱。MK-3207可用于偏头痛研究。
T73703	(3R,5R,6S)-Atogepant
	(3R,5R,6S)-Atogepant ((3R,5R,6S)-MK-8031) 是Atogepant 的异构体.Atogepant 是降钙素基因相关肽受体 (CGRP) 拮抗剂。Atogepant 可用于研究偏头痛。
TP1131	β-CGRP, human TFA (101462-82-2 free base) CGRP-II (Human) (TFA),Human β-CGRP (TFA),β-CGRP, human TFA
	β-CGRP,human tissue is one of the calcitonin peptide, through complex behavior of calcitonin receptor like receptor (CRLR) - and receptor activity - modifying proteins (increased), and 1 and 300 - nM CRLR IC50s/RAMP1 and CRLR/RAMP2 cells.
T76678	Eptinezumab
	Eptinezumab为人源化单克隆抗体，主要通过与降钙素基因相关肽(CGRP)结合，进而阻止其与受体相结合，用于成人偏头痛的预防。
T75934	AC 187 TFA
	AC 187 TFA 是一种有效且具有口服活性的胰淀素受体 (amylin receptor) 拮抗剂，IC50为 0.48 nM，Ki 为 0.275 nM。AC 187 TFA 对胰淀素受体的选择性高于降钙素和 CGRP 受体。AC 187 TFA 具有神经保护作用。

化合物

Vazegepant hydrochloride

Cat.No: T8682

Synonym: Vazegepant HCl

Target: CGRP Receptor

Cat.No: T17194

Synonym: MK-1602

Target: CGRP Receptor

Calcitonin (salmon)

Cat.No: TP1040

Synonym: 鲑降钙素,Calcitonin salmon,Salmon calcitonin

Target: CGRP Receptor

Cat.No: T12293L

Synonym: BIBN-4096,BIBN 4096BS

Target: CGRP Receptor

Cat.No: T4610

Synonym: BMS 927711,BMS-927711,BMS927711,BHV-3000

Target: CGRP Receptor

MK-3207 Hydrochloride

Cat.No: T6590

Synonym: MK-3207 HCl

Target: CGRP Receptor

CGRP antagonist 1

Cat.No: T13453

Target: CGRP Receptor

CGRP 8-37 (rat)

Cat.No: TP1323

Target: CGRP Receptor

HCGRP-(8-37) acetate

Cat.No: TP1134L

Synonym: HCGRP-(8-37) acetate (119911-68-1 free base)

Target: CGRP Receptor

CGRP (83-119), rat TFA

Cat.No: TP1200

Synonym: Calcitonin Gene Related Peptide(83-119), rat TFA

Target: Others

Adrenomedullin (AM) (22-52), human acetate

Cat.No: TP1257L

Synonym: Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base）

Target: CGRP Receptor

β-CGRP, human TFA

Cat.No: T75978

Cat.No: T30537

Synonym: BMS694153,BMS 694153

Cat.No: TP1134

Synonym: Human α-CGRP (8-37)

Cat.No: T70820

Cat.No: T16093

Synonym: MK-0974

Target: Others

Cat.No: T39522

Cat.No: T38734

Synonym: Zavegepant,BHV-3500

α-CGRP(human)

Cat.No: TP2044

Synonym: α-CGRP (human)

[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat

Cat.No: T76363

Cat.No: T26796

Olcegepant hydrochloride

Cat.No: T12293

Synonym: BIBN-4096 hydrochloride,BIBN4096BS hydrochloride

Target: Others

CGRP(83-119), rat

Cat.No: TP1203

Synonym: Calcitonin Gene Related Peptide (CGRP) (83-119), rat

Cat.No: TP2049

Cat.No: T21558

(3R,5R,6S)-Atogepant

Cat.No: T73703

β-CGRP, human TFA (101462-82-2 free base)

Cat.No: TP1131

Synonym: CGRP-II (Human) (TFA),Human β-CGRP (TFA),β-CGRP, human TFA

Cat.No: T76678

Cat.No: T75934

Cat. No.	Product Name	Target	Signaling Pathways
T21581L	AC 187 Acetate AC 187 Acetate (151804-77-2 Free base)	Amylin Receptor	GPCR/G Protein
	AC 187 Acetate 是胰淀素受体的强效拮抗剂。AC 187 对胰淀素受体的选择性高于降钙素和 CGRP 受体。
TP2167	β-CGRP, human acetate β-CGRP, human acetate (101462-82-2 free),CGRP-II (Human) (acetate),Human β-CGRP acetate	CGRP Receptor	GPCR/G Protein; Neuroscience
	β-CGRP, human acetate 是降钙素肽之一，通过受体活性修饰蛋白 (RAMP) 和降钙素受体样受体 (CRLR) 的复合物发挥作用（对于 CRLR/RAMP1 和 CRLR，IC50：1 nM 和 300 nM /RAMP2 在单元格中）。

天然产物

Cat.No: T21581L

Synonym: AC 187 Acetate (151804-77-2 Free base)

Target: Amylin Receptor

β-CGRP, human acetate

Cat.No: TP2167

Synonym: β-CGRP, human acetate (101462-82-2 free),CGRP-II (Human) (acetate),Human β-CGRP acetate

Target: CGRP Receptor

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